Does CBD Stop Pain? How CBD Oil Affects Chronic Pain and Inflammation by Thomas DeLauer

I promised a six month series talking about
I’m going to do one video a month over the
course of six months talking about CBD and
how it affects the body and endocannabinoids
and our natural production of them.
This is mainly just to combat a lot of the
nonsense that’s out there.
All right.
Today, I want to talk about pain and inflammation,
and how CBD affects it, but also how our natural
endocannabinoids affect pain, and how the
modulation of inflammation is really just
a natural process that all has to do with
cyclooxygenase enzymes and also very specific
things called endocannabinoids.
All right.
Let’s talk first about what inflammation really
I’m going to make this quick.
All right.
Inflammation is simply a response to any kind
of trauma or any kind of immune event in your
body, where your body needs an immune response.
Okay, we have two different kinds, acute and
Acute is the kind that you probably know about.
When you bump your elbow, when you get a scratch
or a cut, and it gets swollen.
It gets swollen and red, that’s simple inflammation.
That’s simple cytokine activity triggering
immune cells to fight a given trauma.
Then, we have chronic inflammation.
It’s the inflammation that’s occurring in
our body all the time, really.
It’s constantly happening.
Sometimes, it’s worse than other times.
This has to do with the fact that our cells
become actually sick and we trigger and immune
response, and then it cascades into this vicious
circle, where the immune system responds even
more, and more, and more, yielding to chronic
Now, normally, when we think of fighting inflammation,
we think of an antiinflammatory.
When we talk about antiinflammatory processes
in the body, we think about something known
as a nonsteroidal antiinflammatory, aspirin,
ibuprofen, things like that.
Yes, those do combat inflammation.
Here’s how they actually work.
They act upon something known as the cyclooxygenase
enzymes, COX1 and COX2.
Cyclooxygenase enzymes are a way to actually
slow down inflammation, definitely, by inhibiting
The problem is, as you probably already know,
nonsteroidal antiinflammatories are hard on
the gut.
The reason they’re hard on the gut is because
they stop the production of both COX1 and
One of those cyclooxygenase enzymes we need
to protect our gut.
You see, we actually need a little bit of
inflammation in our gut.
Anyway, I digress.
I want to talk more about how CBD directly
affects inflammatory responses within the
We have these things in our body called endocannabinoids.
They’re endogenous cannabinoids.
A lot of times, when we think of cannabinoids,
we think of only something that’s coming from
cannabis, something that’s illegal, or something
that really is an exogenous thing coming in.
The reality is, we have endogenous cannabinoids.
They’re called endocannabinoids and they have
an antiinflammatory effect on the the body.
They are a very natural thing.
They’re a natural byproduct of fatty acid
metabolism, believe it or not.
These endocannabinoids are naturally occurring
members of what are called the eicosanoid
If you watched some of my other videos, you
know that I talk about eicosapentaenoic acid,
also known as EPA.
If you’ve ever bought a fish oil pill or any
kind of omega 3, you’ve seen eicosapentaenoic
acid, or EPA, on the label, an antiinflammatory
fat that modulates inflammation and does a
multitude of other things within the body.
Well, these endocannabinoids are a naturally
occurring member of that super family.
Within that family, we have a lot of different
things that modulate inflammation.
In this particular case, endocannabinoids
are derived from long chain fatty acids.
They are a byproduct of the breakdown of long
chain fatty acids, meaning it’s a very natural
process to have cannabinoids in our systems.
What ends up happening is they’re produced
by fat.
Then, when they’re actually needed, when they’re
actually solicited to be used for something,
they’re released by the neurons.
We have these fats that are broken down, and
we end up with these overall cannabinoids,
but they don’t get released until the neurons
say so.
The neurons actually see some inflammation
or they see something, they’re going to release
more od these to modulate it.
It’s this natural progression of fats communicating
with neurons to ultimately release these endocannabinoids.
Let’s take it a little bit further to understand
how this works.
Now, that means we have to understand cytokines.
You see, cytokines are signaling proteins
that ultimately recruit inflammation to happen.
Cytokines will trigger specific immune cells
to release inflammation or actually even reduce
inflammation, when given the right circumstances.
Cytokine activity is not always bad.
We do need some cytokine activity.
If we got rid of all the cytokines, we wouldn’t
ever have inflammation or it wouldn’t ever
be able to be modulated up or down, leaving
us in a really sticky situation.
When we get down to CBD, CBD actually modulates
the cytokine production.
It works on cytokine production with very
specific cells though.
Since we don’t want to get rid of all the
cytokine activity, we do want to get rid of
it with specific things.
So, very specific immune cells that overactive
that are causing inflammation in our joints
all the time or causing inflammation in our
brain, they can be become reduced with the
instance of CBD being in the equation, simply
because now we have all the stimulation of
these natural endocannabinoids to reduce that
There’s one specific area of the body that
reduces cytokine activity that’s exceptionally
important, and that’s when it comes down to
T helper cells.
If you ever heard of T cells before, then
you know that there are two kinds.
There are helper cells and there are killer
The helper cells travel around the body and
they slap a label on anything that is potentially
That label allows the killer T cells to come
by later and designate that to be killed.
Basically, has a label, and now the killer
T cell goes ahead and it kills it, so they’re
working in tandem, a two part equation here.
What CBD does is it limits the cytokine activity
of these helper T cells, meaning they are
not as activated in a bad way.
If you have overactive T cells, T helper cells,
they’re going to run around your body, running
rampant, slapping a label on everything, triggering
inflammation and triggering killer T cells
to come around and start an attack on things
that don’t need to be attacked.
You can see how this can lead to a massive
amount of chronic inflammation leading to
joint pain, brain fog, digestive discomfort,
all kinds of different things.
To help this get in really, really, clear,
I’m going to break down one specific kind
of endocannabinoid.
Now, there are a multitude of them, but this
particular one is very common and it’s one
of the most well researched.
It’s called anandamide.
Anandamide is a naturally occurring cannabinoid.
It’s a endocannabinoid that, by using CBD
oil, your body naturally creates more of.
Remember, I’ve talked about this in other
videos, but CBD does not react with the CBD1
and CBD2 receptors.
It does not do that like traditional cannabis
It’s not a recreational drug.
What it does is it allows your body to naturally
create more of the endocannabinoids that are
Endocannabinoids, like Anandamide.
Let’s talk about how that actually works.
Not only does CBD naturally increase anandamide
as is, it also reduces the cytokine activity
that would normally inhibit it.
We’re talking about the cytokine activity
associated with Tumor necrosis factor 1 alpha,
TNF1-a, very, very, common in the world of
By reducing TNF1-a, we reduce the body’s ability
to fight off production of anandamide.
By reducing the activity of Tumor necrosis
factor 1 alpha, we also reduce the activity
of aminohydrolase.
This is a byproduct of fatty acid metabolism
that can actually have a negative effect on
overall endocannabinoid activity.
Basically, all this means is, by reducing
the cytokine activity of these two things,
we are allowing endocannabinoids to do their
jobs better, and we are allowing anandamide
to come into fruition, and we create more
of it.
If you don’t know anandamide, it is very much
so responsible for creating bliss within the
body, reducing inflammation in the joints,
but also reducing inflammation in the brain.
It truly is known as the bliss product of
the body, because that’s the sensation that
best describes what anandamide does.
In knowing that, we have to wonder, well how
exactly does it do that?
Well, it’s because it holds the key to be
able to turn off nuclear factor kappa B, or
at least greatly reduce it.
Nuclear factor kappa B is one of the most
widely researched inflammatory substances
within the body.
It is basically the master control switch,
when it comes down to inflammation.
If we can reduce nuclear factor kappa B, we
can reduce the actual DNA result of inflammation
within our body.
You see, if nuclear factor kappa B is always
elevated, it can change our DNA to be used
to having high amounts of inflammation.
So really, anandamide is one of the keys to
actually getting rid of this problem where
our bodies are getting so accustomed to inflammation
that we’re just adapting to become these inflamed
It truly is allowing our body to turn off
that master switch when it comes down to inflammation.
Mind you, it is doing this all without ever
activating CBD1 or CBD2 receptors within the
I will say that again.
It does not affect CBD1 or CBD2 receptors
in the body.
A lot of marketing collateral out there will
tell you that CBD oil does directly affect
one of the CBD receptors.
Not that case at all.
All CBD oils do the same thing.
They naturally increase the production of
our preexisting endocannabinoids.
Very, very, critical.
I know this was very in depth.
I was talking about cytokines.
I was talking about all kinds of inflammatory
markers in the body, but it’s important that
you know that, at the end of the day, it is
a solid way to modulate and reduce inflammation
in the body without acting about the cyclooxygenase
enzymes that are going to destroy your gut
and lead to a lot of other damaging things
in your life.
As always, if you like these CBD videos, let
me know down in the comment sections below.
I’m going to make sure I keep them coming
to you for the next couple of months, so that
you have a solid understanding of what truly
is going on in the products, but also what’s
going on in your body, not just in a product
that you take.
I’ll see you in the next video.

William Babineau


  1. I cant find anywhere on the website that talks about extraction process. That's one of the key things that makes my buying decisions

  2. thats one hell of a kitchen…pallets for work surface…..recycling at its best, this guy knows what he is talking about.

  3. I think we were lied to about CBD… I'm having such incredible results that I decided to start a home business while I use it. I'm getting older and I'll Never be able to retire Financially, So, I'm looking ahead and hoping to build a little Biz I can do from home and enjoy the benefits of the Product. if ya need some go to: www.ThisIsMyTube.com Thanks

  4. Best Explanation Ive ever heard in regards to inflammation in the body AND how CBD works ! Thank you a thousand times over for sharing such in depth information for better understanding!

  5. CBD gave me my hands back. 30 years of using my hands at work cured by CBD. Can't wait for cannabis to go legal in my state.

  6. Thank you for the break down. I have neuropathy. I believe that the medicines I take for the pain are destroying my body. With the neuropathy destroying my quality of life I often feel like there is not much hope for me. I want to go all natural. I have a newborn grand daughter. I want to live. I want to play with her. I want to watch her grow. Where can I buy this? Thank you again for your help. You are saving lives. Please continue teaching and guiding us. Many blessings to you and your young family.

  7. My question is will CBD oil help the inflammation I have in my knee after having had a total knee replacement the end of October 2018! I still have alot of swelling and a lot of pain in my knee joint! Thankfully the muscles in my leg are beginning for feel better thanks to using sombra on them 3 or 4 times a day as well as alot of ice and my tens unit!

  8. I ate 36mg of cbd gummies.
    I was knocked out and had a body fry.
    Googly vision and super tired.
    I actually can still feel it the next day.
    Kinda like the "stupid" day or the next day after smoking a lot of weed back in high school or the first time I did..
    My girlfriend and I actually got the giggles from cbd gummies.
    Cures brain fog? Not me..

  9. Dude, we get it, you're a beautiful genius! Why don't you drop the jargon, put a shirt of and explain shit in plain English? Anyone with half a brain who's "not a pot smoker" isn't going to have the attention span needed to follow along. I avoid your videos as soon as I see them.

  10. I had a Opiate addiction for a while . I was put on Suboxone and I hate it I take very little but need help getting OFF . I was told that CBD oil binds to the same receptors in the brain giving a similar feeling of well being and helping with the depression of getting off these types of Meds . Without risk of any addiction . If this is true whats a good dose to start at ? I'm 53 and was Athletic for many yrs so have plenty of aches and pains it should help with as well .

  11. You sound like a scientist so why hasn’t the doctors and the pharmacies had scientists do a real survey to see the CBD can help people because it’s all about the money big pharmacy marijuana CBD they all get paid to tell you truth I think it would be cheaper to make CBD?? , with no regulations lots of scammers selling CBD

  12. Great video, but please stick to just the basic facts on your videos! Those are the same comments I hear about all the time about all your videos … that they are too lengthy, with a lot of unnecessary info!

  13. >CBD is not what it claims to be…Pure expensive and useless Snake Oil crap. Used it for 2 months, spent 150 dollars and NO fffkkkkg results.

  14. How long does it take to get in your system to make you feel better

  15. Great video, even though he was talking over my head at times. But I came away with a better understanding of the positive properties in cbd.

  16. I'm just starting on Cbd oils. I love in Virginia & it just got legalized here. I've had 26 surgeries from arthritis including 3 knee replacements, back surgeries 9 knee surgeries, & several others. I also have had a spinal simulator put in & its not working like I thought it would. I also have ptsd, fibromyolgia, iritisis, ddd, gastritis, ibs & a few other things wrong. I'm expecting my first delivery of cbd oil tomorrow. What amount is suggested for me?

  17. This is the most informative, well spoken video on the topic and you are very well informed. I have fibromyalgia and this video has given me a lot to think about and lot more hope of reducing my inflammation and pain. Thank you.

  18. Too mutch guns but no forearms what so ever. Over all bet he has chicken legs too lol 😂

  19. I really enjoy your videos!!! Can you talk about CBD disposable vape pens work essential oils ie the brand Select? Thank you! I plan to follow your videos as I understand CBD OIL much much better!!

  20. Can you list reputable CBD oil brands. There are so many on the market and a lot of them are garbage.

  21. I definitely believe in what you're saying, it just seems there are so many comingling factors, that any one element in that chain is off or broken or too much or too little, it will either not work or be detrimental to your health.  Which is not to say I'm not going to try it, evidence seems for the most part positive, and I'm tired of being in pain.

  22. Do you recommend any specific brand or brands? I feel there seems to be so many claims about theirs being the best. Your help is greatly appreciated!

  23. Great! I just don`t understand why do you hide this content here and don`t put it on your main channel.

  24. Hello, I would like to know the level of your health degrees? What schools you attended and graduated from and what your thesis was on….. The reason why I say this is a simple one. Way to many people here on youtube claiming to be experts. The most MAJOR thing you don't speak of with real CBD oil is the effect to and on the brain itself. You only speak of inflammation. The true tract of what CBD oil does to the entire human body is vast and expansive, the health benefits are almost miraculous and I not only see it but am part of it…. Below is part of a response that I wrote to 6 different people here on youtube claiming that CBD oil does nothing….. Imbeciles that bought hemp oil sold in almost every state which is not real CBD oil…. Due to their own ignorance and wanting to be youtube stars they are filling the airwaves with false knowledge that can and will hurt real people in need and that will never try this due to what they hear and see by these people…. FIRST, Number One: What Oil are you taking and from what company. There is a huge difference between Hemp Oil and CBD Oil, (did you even know this before you came on here?) What MG was the dose? How often did you take the oil? How many times a day did you take the oil? Do you know the facts and the specifics of what you are even talking about and what you are taking? …………………….. Here are the facts. My nephew was born premature at 4 months old. Boston Childrens Hosp. He was born with Cerebral palsy, Blind and distorted for life. Up until 5 years ago he had up to 30 seizures a month, being flown into BCH 4 to 5 times a month. My brother finally decided to use REAL CBD Oil at 1000mg per 10 ounce…..Not the crap hemp oil you can buy at any store or online like you most likely bought. My Nephews seizures went for 20/30 a month to 1 every 3 months. Two of his doctors now come every month to my brothers home to record what is taking place and plan to announce their findings to the New England Journal of Medicine in One more Year! (They have been recording his results now for 4 years) NOT ONLY has the REAL CBD Oil stopped his seizures (3 drops under the tongue and any of his seizures stop withing 60 seconds) But his neuro pathways are regenerating and reforming in his brain. That means his brain is starting to heal itself………… Now for another fact: I have 5 herniated discs, Had thyroid cancer, Lung disease due to chemical overexposure from work its called RADS, Reactive airway dysfunction syndrome, its incurable and I will eventually die from it………………….. I've been on REAL CBD Oil for 14 months, (Not the Hemp garbage in every state being sold)) …I am off all Diabetes Medicines (2 different insulins and pills daily) I am off my inhaler that I had to use Every day, and I have worked down 3 notches of pain meds that I had to take 4 times a day…….. Real people Using REAL CBD Oil are getting tremendous results…………………..So PLEASE Stop being complete morons and coming onto YOUTUBE to be Star of the Day…… You most likely are using a cheap ass hemp oil you bought online or in a vape store, Not real CBD that you would either have to get through your Doctor………………..Your false claims using false products does Harm to real people that could benefit from using real CBD Oils…………………For God Sakes do real Research before you even think about shouting out to the general public………………………… If you have used a garbage product of hemp oil that you bought at any local store then please delete this entire blog and video, if this is the case you should be ashamed of yourself and at least get real facts information and products before you do this again. Real people, real pain and real life, act responsible.

  25. i'm confused. all i know is that cbd did nothing for my pain. i just have to live with it as i don't like the things that doctors do to people and i'v tried all allied health which did nothing to so after 29 years i can only say that my chronic pain is my best friend!!

  26. One should consider taking all natural CLE Mineral Drops stop stop pain and inflammation in the body. It works so well but it works with the human system to reverse the condition.

  27. Great video. Not sure if you're monitoring the comments or not but you accidentally say CBD1 and CBD2 receptors. I think you mean to say CB1 and CB2.

  28. CBD was used by the INCAS..now after centuries we "rediscovered" it, about time i'll say! Sorry(not really) Tylenol, Advil, etc. business are going down!

  29. This has been very helpful! I've been dealing with inflammation for past 20 years. I'm allergic to NSAIDS so all Dr gave me was prednisone. I've recently discovered CBD, it's been very helpful & this video is very helpful.

  30. Dude, you're so fvckin smart it's not even funny. I had trouble following at times 🙂 I love your content, however, I would really appreciate it if you would say "it's kinda like X" every time you describe some crazy chemical process that happens in the body and use some simple analogy to help explain it further. Just a suggestion. Keep up to awesome content coming. Thank you!

  31. Not sure if you have the time to answer my question, however it’s worth a try. I suffered a shattered fib/tub, and four surgeries and now a broken plate. Long story short, I developed chronic eczema three weeks after the last surgery and have been unable to find any relief. Any suggestions would be greatly appreciated.

  32. Can one expect the same benefits when using tinctures? I live in NV, and cannibis products are legal here. CBD can be purchases easily, but most CBD products are mixed with varying levels of THC. You can get straight CBD, but it's really expensive. Does the THC mixed CBD reduce the health benefits?

  33. Question…..If CBD oil works so great for just about everything. Then why does eating or smoking high quality weed just get me really high and does little to nothing for my pain? I can also pick fully mature wild hemp buds in the fall loaded with mature seeds and eat a fresh 4 ounce salad of hemp seed/buds and it does nothing for my pain. So I don't understand how this CBD oil can work so great for everybody. If weed and hemp does nothing for pain, is CBD oil the concentrated CBD extract of say, 15 mature plants into 1 little vial?

  34. I’m a medical professional and am impressed with not only your pronunciation of these terms, but also your speed. Seriously, good job.

  35. If you could just speak in layman's terms it would be deeply appreciated. Information you are giving us is above everyone's head. We need positive information we're not stupid so please stick to the subject and answer the question how to use CBD does CBD actually work how long should you use it.? Thank you sincerely Arnold Bourbon Amaral

  36. Best pain relief for chronic pain, is called the entarauge affect. I use cbd first wait 30 mins, take 2 riffs off bong and get better relief then cbd by itself. Just for me, maybe not for you. But I've had chronic pain from 5 failed back surgeries, been on all the pain pills. FOR MEE, it works best if used in conjunction with some good India. As I said this is what works best for ME.

  37. I have a question regarding CBD Isolate and cbd full spectrum. I can’t take the full spectrum due to random drug tests and my jobs zero tolerance policy. Do the isolate tinctures and vape products have the same effect or is full spectrum a must?

  38. CBD is not tested. magnesium will do 10x better than CBD.

  39. I have fibromyalgia it's . central nervous system pain pathway neurological pain. Do you recommend any sort of CBD oil or marijuana to help with the pain other than using opioids. I'll keep in mind there is no inflammation in fibromyalgia that's some big misconception everyone's had it's up maybe 10 or 15 different feelings of pain so this is all stemming from nervous system in the pain Pathway to the brain I tried a cannabinoid in a tablet and a capsule but it didn't have any effect whatsoever so I'm just wondering is it wasting my time to go and purchase and get a prescription for it or should I just stay with the opioids. As you know fibromyalgia has been around for a long long time back when they called it rheumatism. Is there such potent medication for sleep insomnia to eliminate seditives and benzo medication. Okay thank you very much for any help you can offer me! You sound intelligent on the topic.

  40. If there's anyone on this platform that doesn't have any sort of acute or chronic pain that is intense and severe you just jump right off the topic as you're trying to learn about something that's different but if you're trying to preach about chronic pain in certain conditions like fibromyalgia you can't make people feel like it's something that isn't as serious as it is.

  41. Whatever you do, make sure you are buying pure CBD. NO GMO’S, NO PESTICIDE, NO ADDITIVES OR FILLERS. Make sure it's ORGANIC & 3RD PARTY TESTED. If you need help finding this, just ask.

  42. I have tried this in a BALM form on my Hands too cut down. Arthritic Pain to no avail. would it work better if in OIL form??

  43. my mom can't use her left arm and hand from stroke can cbd make new cells in the brain then she can use it?

  44. What r ur thoughts about Irwin Naturals CBD line? I only ask due to your clear expertise but also because they are so far the one product that’s affordable for me. Thank you!!! 💘👍

  45. Well, the out of control T cells when misbehaving result in autoimmune disorders.

  46. It doesn't work for me. At all. The only people I see who say it works is the people who sell it.

  47. So does it matter if it's full spectrum CBD or pure? I've read before that only CBD-A is able to reduce pain. Problem is there is less CBD-A in a full spectrum product than THC, which by law has to be less than .3%. I take 80mg full spectrum once or twice a day for degenerative disk in my Cspine. It helps, but doesn't eliminate.

  48. One of my best videos explaining inflammation I've seen….Good job!

  49. CBD is known for its uncanny ability to treat pain and inflammation. Thomas Delauer discusses exactly how CBD works in the body to make you feel better. Has CBD helped you with chronic pain? Please share your experience in the comments below, and feel free to ask any questions. Visit us at https://www.octagonbiolabs.com

  50. You're driving me nuts saying CBD1 and CBD2….it's CB1 and CB2!!! Get it right…

  51. It’s CB1 and CB2…not CBD1 and CBD2. Can’t stand hearing you say that. It makes you sound uneducated. It’s also anandamide not andandamide…good presentation but get your words right

  52. Back in February I had a hard time closing my fists on both hands. I have never had that problem.
    I heard on the local radio station a little store that opened about a mile from the house. The commercial said they were selling lotion that had CBD oil in it. I figure what the heck. I could go to the doctor and get some pills and have a dozen side effects or try this.
    I went down to the store on Saturday. I purchased about a 4oz bottle of this cream called Bud’s Deluxe. They have it in 250mg, 500mg, 1000mg and 1500mg strength. I got the 500mg and went home. That day I put it on the back of my hands on my knuckles. On Sunday I applied and 2nd coat.
    Monday morning when I woke up I could make a tight fist and snap my fingers! Wow this stuff works. I told some elderly ladies about this and one went down to the store, https://the-smoking-pot-coffee-shop.business.site/
    Their address is 8510 Long Point Rd. Houston, Tx I picked up a container (pump top applicator).
    The next week I ask if it worked. She said her shoulder pain went away. She even put it on her neck for pain and that went away.

    Who would ever think that stuff works. This was right under our nose for decades. You want to keep it out of the food and drug business, as they will say it no good and try to control it.

    Maxwell House Coffee plant here in Houston closed up about a year ago.
    Another company is coming in and are processing the hemp plant to make the liquid drops and cream. They are going to put 500 people to work.

    Farmers in Texas are gearing up to raise the hemp under strict quality control.
    I can say I can snap my fingers like I used to when I was 32 years old !

    Thanks for reading…..

  53. Sir/ Maam please tell us where to buy your product CBD cream/oil for arthritis pain thank very much

  54. So the oil basically helps balance your body. Benefit in a healthy way.

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